User Reviews for Memantine to treat Alzheimer's Disease. Do some research, ask a question, get an answer. From experience the tolerance issues come heavily into play when dosing more regularly or for a longer period than this. It is taken by mouth. MDL number MFCD00214336. Memantine is used to manage moderate to severe Alzheimer's dementia Label.. A more recent systemic review and meta-analysis 6 indicates that memantine is beneficial as a first line drug for the treatment of Alzheimer's dementia. I got a little bit of double vision as this dose, with a slight amount of other dissociatives visuals, mainly scenery slicing. A friend of mine liked it so I just gave it to him. 348. Do some dreaming, ask a question, get a ban. Press question mark to learn the rest of the keyboard shortcuts. This had me feeling pretty nice. Confused 2. I had pretty intense close eyed visuals for most of the night, not really knowing if I slept at all when I got of bed the next day. Trying 50mg Memantine tonight. Overview; Side Effects; Dosage There's no element of confusion at all. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. So I'm seeing a psychiatrist to see about getting back on my vyvanse in order to help with going back to school(I would just use RC stims as they work better, really, but I'm getting put on probation in two weeks and have to take hair follicle tests). Warnings and Precautions The 2nd time I honestly didn't notice much of an inebriation at all, all in all this seems to be a fairly "clear-headed" dissociative in my opinion. Constipation 3. Memantine is a primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane.A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. NAMENDA oral solution contains memantine hydrochloride in a strength equivalent to 2 mg of memantine hydrochloride in each mL. I am interested in getting it again though and using it for tolerance to stimulants because long story short, I have crippling anxiety, have used benzos for it, they make it way worse and have caused a lot of problems for me, I've basically came to the conclusion that I'm anxious because of confidence issues. And personally, I've never had a bad time while under the influence. Memantine: Formulations, Dosages, Contraindications, and Side Effects. I read that as mermantine and got very excited. I personally have replaced all other dissociative use (including a previous Ketamine addiction, and regular DXM use) with Memantine. 6.1 Clinical Trials Experience. Ask questions about drugs that you already typed into google, After the slow and painful death of MXE in 2015, researchers of the research chemical community have been searching for a replacement. Haven't felt any Euphoria yet within 2hrs of taking it initially at 10.00pm. Dizzy 6. A sub dedicated to PCP, Ketamine, MXE, Diphenidine, DXM, MK-801 and more! Definitely a much clearer headed high than other dissociatives, lacking most of the traditional body high in exchange for a more cerebral oddity type feel. Sourcing drugs is NOT allowed here! When in doubt, DONT. Dissociative Chemical Diffefence Image Chart: M.A. Ill continue later.... New comments cannot be posted and votes cannot be cast, More posts from the MemantineHCl community. A subreddit dedicated to people who have there own drug gardens. I was able to mix 50 mg of memantine hydrochloride into 1 ml of distilled water only after applying light heat to increase solubility. Theres also a memantine powder vendor on reddit, with great prices. If you don't see your submission or have a problem feel free to message the moderators. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. Memantine HCl is an antagonist of NMDAR.It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, … The 3rd time I took 150mg, followed by another 150mg about 4 hours later. I will personally be compiling user reports from erowid and any pre-existing reports on reddit, but there is limited information available. Whether you have experience with them, are new to them, or are new to the subreddit, we welcome all. Make sure you follow the RULES. The supplements subreddit aims to discuss and share topics related to nutritional supplementation. Take this medication by mouth with or without food as directed by your doctor. One interesting memantine side effect includes higher libido. I've taken memantine at 20mg/day for ~3 months, effectively, and recreationally/experimentally, once at 50 mg-common dose (effects: gnawing hunger/empty feeling in stomach, dizziness/"whoosh" feeling when moving my head, increased interest in everything, less/no fidgeting/increased concentration). Memantine hydrochloride oral solution is a prescription medicine used for the treatment of moderate to severe dementia in people with Alzheimer's disease. Dawkę, okres oraz częstotliwość stosowania ustala lekarz. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. Memantine is a useful nootropic in the 10mg-60mg range daily, ONCE YOU GET USED TO IT, which can take a couple months, and slows opiate and stimulant tolerance buildup a bit. This drug will pretty much wreck your dissociative tolerance, so don't plan on getting much fun out of any other dissos for weeks or maybe months after a recreational dose of memantine. ), and general discussions on different categories of supplementation. So I first started using Memantine to help reduce tolerance for dextraomphetamine which I take daily for ADHD. Also you mentioned this 'doll-house' type effect, I've been coining the term 'Memanverse' to describe what I think you are saying. Whether its a question, picture, or information. We are here to discuss all dissociative chemicals, reports, trips, possible chemical synthesis, and any sources you may come across. Vision is clearly distorted and physical balance is off. This is a subreddit about DPH. It just takes time. Store memantine at room temperature away from moisture and heat. Pictures and discussions. (r/drugs with longer words). * Chemistry-related DPH stuff For the discussion of recreational pharmacology. on the real, a place for humans who prefer to go fast (in whatever way they like) to come together, commune, communicate, share stories of our lives, ask questions, share knowledge (always in the interest of harm reduction), make friends, and revel in the wonders of life. It is less preferred than acetylcholinesterase inhibitors such as donepezil. https://erowid.org/experiences/exp.php?ID=109838, https://erowid.org/experiences/exp.php?ID=109789, https://erowid.org/experiences/exp.php?ID=105696, https://erowid.org/experiences/exp.php?ID=100894, https://drugs-forum.com/threads/100mg-memantine.248883/, https://erowid.org/experiences/exp.php?ID=32398, https://drugs-forum.com/threads/memantine-experience.286366/, https://drugs-forum.com/threads/memantine-experience-high-dose.296411/. Does Memantine HCL Interact with other Medications? Check out the /del/ discord: https://discord.gg/G3yV8Te, Tianeptine (Stablon) Discussion & Experiences. Cholinesterase inhibitors may be added to memantine for further beneficial effects on behavioral symptoms and other … The tablet can be divided into equal doses. I can already say this is my alternative to DXM. Please also state how often you are dosing and with what dosages, and please describe roughly what you believe your tolerance to be. Granted, it may not be for everyone, but to say it's an objectively 'awful' recreational drug is incorrect. The only positive is it's pretty good at getting rid of anxiety, your brain isn't working enough to be anxious. Memantine hydrochloride 20 mg film-coated tablets are * Combinations you tried or want to try I'm also a woman of normal height and weight (5'6"; 125 lbs). The FDA has officially approved memantine for the treatment of certain cases of Alzheimer’s disease, and this is the most typical medical use of memantine. Molecular Weight 215.76 . memantine Hydrochloride Tablet is contraindicated in patients with known hypersensitivity to memantine hydrochloride or to any excipients used in the formulation. Memantine. I was pretty dissociated but it lacked the euphoria and pretty much any 'fun' aspect of a recreational dissociative. The next day, I often feel achey and sore all over. Discussion of all things related to the narcotics known as opiates, from harm-reduction to pharmacology. So I've tried memantine at recreational doses about 3 different times now, this is what I have to report. A subreddit for all benzodiazepine users to gather to discuss all things benzo related. We are a migrant community mostly from the previous sub NovelDissos. Definitely has similar numbing qualities as other dissociatives. But it is an absolutely awful recreational drug- taking, without tolerance, any amount, but particularly an amount above 30mg just makes you feel braindead and generally shitty. All I can say is its a very clean dissociative. A psychonaut is a person who experiences intentionally induced altered states of consciousness and claims to use the experience to investigate his or her mind, and possibly address spiritual questions, through direct experience. If experienced, these tend to have a Less Severe expression 1. Pictures of drug and paraphernalia collections, and large amounts of drugs. There are common reports of an uncomfortable slowing of thought processing, but for many it isn't enough to warrant dislike of the drug. 1st time, 100mg : This drug takes a while to come up on that's for sure. I don't remember the exact dosage, but it didn't exceed 150mg. Feel free to share helpful hints, tips, and news about kratom. There is some clinical evidence that it can help people recover from stimulant and opioid addictions. I didn't feel much with the first dose, possibly due to an increased tolerance since it wasn't super long since the last time I took it, (which I do not recommend... apparently taking it to often can fux with neuroplasticity levels), but a few hours after the second dose things got pretty warbly. Confidence issues are because I feel that I haven't accomplished anything in my life besides a highschool diploma. A sub for discussing all uses of Memantine, from therapeutic to recreational. Once you finally feel the urge to go curl up in your bed under your blankets, don't be surprised if you sleep for 16 hours straight. As it stands the dosing range on Memantine's Psychonaut Wiki page was submitted by a single user with unknown sources. It's a looooong trip. We are a community of dissociative enthusiasts and harm reductioners here to discuss the effects, safety, and a list of other things that all have to deal with dissociatives! Head Pain Very pleasant dreams. It's difficult to tell if you've reached the Mem-Hole or not, because in my experience, to really achieve it you have to find a very calm place, allow your mind to drift and more or less meditate for a lack of a better term, until you've disconnected from reality. what should I take? Memantine, or known as Memantine HcL, is an uncompetitive NMDA receptor antagonist, and thus relies on glutamate’s activation of the NMDA receptor to take effect. If there's any questions I'll do my best to elucidate on the experience, hope this helps! Maybe in spite of that, someone likes it- but I'd be willing to bet a large amount that such a person would like a traditionally recreational disso a hell of a lot better. You can read more specifically which term describes what range of effects here. I weigh 120lbs-125lbs. A place to discuss obscure drugs. I have one question for you:If you've taken 300mg in about a 4 hour period, how much would you think you would need to reach the "Mem-Hole"? Memantine hydrochloride oral solution belongs to a class of medicines called NMDA (N-methyl-D-aspartate) inhibitors. A sub for discussing all uses of Memantine, from therapeutic to recreational. A dedicated subreddit for the discussion of synthetic psychoactive research chemicals. While being very dissociated, I'm able to think properly and rationally. Memantine Dosage. This is yet another reason why I love this substance, I don't think I've had such a clean and clear headed disconnection from reality without feeling heavily impaired at the same time. http://scs-assets-cdn.vice.com/int/v18n2/htdocs/interview-with-ketamine-chemist-704/drug-structures.gif. I am done with my experimentation. This extends into what is the Memantine equivalent of a K-hole, which when compared to Ketamine is much more clear-headed. Thanks for the insight, I know you're one of the first other recreational users I came across on reddit. For all your inquiries/input/general information about using GABAergic Drugs (Phenibut, Gabapentin, Benzo's etc). 31% of those users who reviewed Memantine reported a positive effect, while 49% reported a negative effect. * Experiences you had with DPH This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. I took 150mg the next day and had a Bon fire. I find myself over-analyzing everything. Serious Interactions. I wasn't noticing much effects(I bought it basically for recreational use but read that even taking this much could be intoxicating after a couple of days). These are currently the few reliable reports of recreational Memantine use: Reported Dose: 150mgDescribed Experience: Heavy (Hole-like experience)Reported Tolerance: unknown, some dissociative experienceSource: https://erowid.org/experiences/exp.php?ID=109838, Reported Dose: 150mgDescribed Experience: Heavy (Hole-like experience)Reported Tolerance: Experienced userSource: https://erowid.org/experiences/exp.php?ID=109789, Reported Dose: 20mg (In conjunction with 600mg of Gabapentin)Described Experience: Threshold-LightReported Tolerance: Zero experience with Memantine, some experience with other dissociativesSource: https://erowid.org/experiences/exp.php?ID=105696, Reported Dose: 100mgDescribed Experience: Common-StrongReported Tolerance: some dissociative experienceSource: https://erowid.org/experiences/exp.php?ID=100894, Reported Dose: 100mgDescribed Experience: CommonReported Tolerance: unknown, user reports previous use of DXMSource: https://drugs-forum.com/threads/100mg-memantine.248883/, Reported Dose: 4x doses ranging between 50-100mg (200-400mg total)Described Experience: HeavyReported Tolerance: unknownNote: recommends 50-100mg for common useSource: https://erowid.org/experiences/exp.php?ID=32398, Reported Dose: 80-100mgDescribed Experience: Light-CommonReported Tolerance: unknownSource: https://drugs-forum.com/threads/memantine-experience.286366/, (From the same thread as above)Reported Dose:50mg (1st Day), 90mg (2nd Day), 160mg (3rd Day)Described Experience:Day 1: (Light), Day 2: (Light-Common), Day 3: (Strong)Reported Tolerance: UnknownSource: https://drugs-forum.com/threads/memantine-experience.286366/, Reported Dose: 280mgDescribed Experience: Strong-HeavyReported Tolerance: unknownSource:https://drugs-forum.com/threads/memantine-experience-high-dose.296411/. Memantine hydrochloride 10 mg film-coated tablets are pale yellow to yellow, oval shaped film-coated tablets with breaking line and engravings 1 0 on one side and R R on the other side. Hunting ethnobotanicles is also encouraged. I would suggest maybe extending the common up to 120 or 130, and upping the strong to 200mg, with heaving being anything 200 and above. A subreddit for the sharing and discussion of research chemical vendors. (Examples: Dexamyl, Placidyl, Diconal, Miltown). Memantine oral tablet is … Keiski, in New Therapeutics for Traumatic Brain Injury, 2017. Don't take phenibut before you understand the risks and side effects. I have a lot of experience. Cough 4. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. But it wasn't very fun. Just wanted to put some stuff out there as there's not a whole helluva lot of reading material on memantine. It's mainly about the recreational use of DPH, but posts about using DPH as it was intended are welcome, too. Memantine, 3-MEO-PCE, LSD, 4-AcO-MiPT, 4-HO-MET, 2C-C, Clonazepam & Aripiprazole: Adventures in NMDA Receptor Antagonism: viscosity: Memantine & DXM: Just the Kick in the Teeth I Was Looking For: 180OnTheDVP: Memantine & Nitrous Oxide: Beyond Tollerance Reduction: Clyde T. When you first start taking this medication, you will usually take it once daily. The self awareness memantine provides is one of the key factors why I enjoy it over other dissos, you can very easily gauge how much it is effecting you and take precautions so your situation is rarely ever precarious. As for your comment about car accidents, any reasonable user should be smart enough and aware of the dangers of driving on any substance, this sub and the other resources available are meant to reduce harm and educate users about the risks involved with Memantine use. I've taken as high as 200mg (with tolerance). And it lasts fucking forever, so you take 100mg and you don't like it, prepare to feel that way for three days and likely have a car accident and some serious amnesia. I'm no stranger to dissociatives so it wouldn't have been too bad if I ended up getting a little inebriated during this process. Get your prescription refilled before you run out of medicine completely. Memantine hydrochloride extended-release capsules were evaluated in a double-blind placebo-controlled trial in which a total of 676 patients with moderate to severe dementia of the Alzheimer’s type (341 patients on memantine hydrochloride extended-release capsules 28 mg/day and 335 patients on placebo) for a treatment period up to 24 weeks. For those who want to use memantine for … For people who enjoy both gardening and drugs. Modafinil (Provigil, Modalert) and related compounds. I then took 50mg in the morning followed by 50mg more in the afternoon. Results: Pretreatment with memantine attenuated the craving for alcohol before alcohol administration, but not after alcohol was given. Memantine is a prescription drug used to treat moderate to severe confusion related to Alzheimer's disease.It does not cure Alzheimer's disease, but it may improve memory, awareness, and the ability to perform daily functions.This medication works by blocking the action of a certain natural substance in the brain that is believed to be linked to symptoms of Alzheimer's disease. r/depressionregimens is a sub for redditors with depression and anxiety who are looking to be part of a constructive community dedicated towards improvement, with a focus on safe and researched substances. Suggested topics include: It has a role as a dopaminergic agent, an antiparkinson drug, a NMDA receptor antagonist, a neuroprotective agent and an antidepressant. I imagine that's because I don't eat enough/keep myself hydrated enough during the previous day. A friend and I went exploring as I just bought this house and it's pretty much in the middle of nowhere. View Entire Discussion (30 Comments) More posts from the Nootropics community. Keep the liquid medicine bottle tightly closed with the cap provided. In conjunction with the psychonaut wiki, we are seeking to create a more reliable and standardized recommended dosing range for recreational use of Memantine. These medications may interact and cause very harmful effects. EC Number 255-219-6. Nutritional supplementation consider supporting Psychonaut Wiki page was submitted by a single user with unknown sources rating of 4.6 of... A less Severe expression 1 've never had a bad time while under influence... N'T accomplished anything in my life besides a highschool diploma //discord.gg/G3yV8Te, (... Has with none of the first other recreational users I came across on reddit with... Hydrochloride, USP occurs as a dopaminergic agent, an antiparkinson drug, but about... 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Pre-Existing reports on reddit: Formulations, Dosages, Contraindications, and open clear... Sore all over I consider trying to trip off benadryl or nutmeg days I was hurting pretty.! Reports, trips, possible chemical synthesis, and general discussions on different categories of supplementation with unknown.. Letting us know how you use memantine intended are welcome, too into the channel to binding! Plant traditionally used by Mazatec shamans a place to discuss all things to... I can already say this is what I have to report a source or powder! Euphoria, pain relief, dissociation, anxiety reduction among other positive.! About as good an idea as trying to trip off benadryl or nutmeg great prices enough the! Subreddit dedicated to people who have there own drug gardens was hoping for understand the risks and side effects,! Molecule classified as a substituted adamantane derivative this house and it 's a lot of material! 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Psychoactive plant traditionally used by Mazatec shamans chemical synthesis, and extended-release capsule amount of other dissociatives,.